| 海藻酸改性的中空SiO2微球的简易制备及应用 |
| |
| 引用本文： | 董丽娟,姚奇志,马芳,金谷.海藻酸改性的中空SiO2微球的简易制备及应用[J].应用化学,2011,28(6):678-682. |
| |
| 作者姓名： | 董丽娟 姚奇志 马芳 金谷 |
| |
| 作者单位： | (中国科学技术大学化学系 合肥 230026) |
| |
| 摘 要： | 以CaCO3为模板，正硅酸四乙酯（TEOS）为硅源，用比较简单的方法制备了中空SiO2；然后将海藻酸钠嫁接在氨基化的中空SiO2表面；再利用海藻酸盐与钙离子的作用，在中空SiO2表面形成一个凝胶化层，制得海藻酸盐凝胶化的中空SiO2微球，粒径为1~2 μm。 采用FTIR、XRD、SEM、TEM和TGA等测试技术对微球进行表征。 此微球成功地用于柔红霉素的载负和缓释，最大载负率和载药量分别为55.6%和27.8%；缓释结果表明，海藻酸盐凝胶化层的存在，能更有效控制柔红霉素缓慢的释放，这种凝胶化载体对药效强、毒性较大的药物有潜在的临床应用前景。
|
| 关 键 词： | CaCO3 中空SiO2 海藻酸盐 微球 柔红霉素 |
| 收稿时间： | 2010-08-05 |
Facile Preparation and Application of Silica-Alginate Microsphere |
| |
| DONG Lijuan,YAO Qizhi,MA Fang,JIN Gu.Facile Preparation and Application of Silica-Alginate Microsphere[J].Chinese Journal of Applied Chemistry,2011,28(6):678-682. |
| |
| Authors: | DONG Lijuan YAO Qizhi MA Fang JIN Gu |
| |
| Institution: | (Department of Chemistry,University of Science and Technology of China,Hefei 230026) |
| |
| Abstract: | Hollow inorganic particles have attracted great interest because of their unique physicochemical properties.In this study,a simple and effective method for synthesizing silica hollow spheres is presented.The synthesis utilizes CaCO3 as spherical templates for the silica growth;tetraethyl orthosilicate(TEOS) is added to the template as a precursor for the silica formation.After CaCO3 spherical cores were removed by adding diluted hydrochloric acid,hollow silica spheres with smooth surface and uniform shell t... |
| |
| Keywords: | CaCO3 |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《应用化学》浏览原始摘要信息 |
| 点击此处可从《应用化学》下载免费的PDF全文 |
