Mono thiomalonates as thioester enolate equivalents--enantioselective 1,4-addition reactions to nitroolefins under mild conditions |
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Authors: | Clerici Paolo Wennemers Helma |
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Institution: | Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel, Switzerland. |
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Abstract: | Mono thiomalonates (MTMs) are introduced as thioester enolate equivalents. Asymmetric organocatalyzed conjugate addition reactions to nitroolefins proceed under mild conditions to afford synthetically useful γ-nitrothioesters with excellent yields and enantioselectivities. |
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