A facile one-pot preparation of 2-methyl-and 2-phenyl-4- fluoro-5-trifluoromethyl-6-methoxypyrimidine from methyl 2-hydryl-2-(F-methyl)-F-propyl ether

The title compounds were readily prepared in one-pot by phase-transfer reaction of a methanol adduct of 2-($\text{F}$-methyl)-$\text{F}$- propene with acetamidine or benzamidine in the presence of aqueous sodium hydroxide in CH₂Cl₂. Various 5-trifluoromethyl- pyrimidines were also synthesized $\text{via}$ nucleophilic substitution of the 4-fluorine of the title compounds.