Light-Activated Rhenium Complexes with Dual Mode of Action against Bacteria |
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| Authors: | Dr Angelo Frei Maite Amado Prof Matthew A Cooper Dr Mark A T Blaskovich |
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| Institution: | Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, 4072 Australia |
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| Abstract: | New antibiotics and innovative approaches to kill drug-resistant bacteria are urgently needed. Metal complexes offer access to alternative modes of action but have only sparingly been investigated in antibacterial drug discovery. We have developed a light-activated rhenium complex with activity against drug-resistant S. aureus and E. coli. The activity profile against mutant strains combined with assessments of cellular uptake and synergy suggest two distinct modes of action. |
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| Keywords: | antibiotics drug design metal-based drugs rhenium |
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