|
|||||
|
|
Lewis acid-catalyzed asymmetric hydroxymethylation of silicon enolates in aqueous media |
|
| Authors: | Kei Manabe Shunpei Ishikawa Tomoaki Hamada Sh Kobayashi |
| Institution: | Graduate School of Pharmaceutical Sciences, The University of Tokyo, CREST, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan |
| Abstract: | Asymmetric hydroxymethylation of silicon enolates with formaldehyde in aqueous media has been achieved using praseodymium triflate and a chiral crown ether. Formaldehyde aqueous solution can be directly used for the reactions, and a water/THF mixture was found to be the best solvent system. This is the first example of catalytic asymmetric hydroxymethylation of silicon enolates. |
| Keywords: | Lewis acid aldol reaction hydroxymethylation |
| 本文献已被 ScienceDirect 等数据库收录！ | |