| 一种新型葡萄糖基化竹红菌素的合成和ESR研究 |
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| 引用本文： | 夏盛钦,陈景荣,王雪松,张宝文.一种新型葡萄糖基化竹红菌素的合成和ESR研究[J].影像科学与光化学,2004,22(5):363-369. |
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| 作者姓名： | 夏盛钦 陈景荣 王雪松 张宝文 |
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| 作者单位： | 中国科学院, 理化技术研究所, 北京, 100101 |
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| 摘 要： | 以巯基乙酸取代的竹红菌乙素和氨基葡萄糖为反应物,只用一步就合成了一种新型葡萄糖修饰的竹红菌乙素.氨基葡萄糖的取代改善了竹红菌乙素的水溶性及其在光疗窗口的吸收,并保持了其产生1O2、O2·-、·OH和半醌负离子自由基的光化学活性.
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| 关 键 词： | 竹红菌乙素 氨基葡萄糖 水溶性 活性氧 |
| 收稿时间： | 2004-05-14 |
Synthesis and ESR Investigation of a New Hypocrellin Glycoside |
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| XIA Sheng-qin,CHEN Jing-rong,WANG Xue-song,ZHANG Bao-wen.Synthesis and ESR Investigation of a New Hypocrellin Glycoside[J].Imaging Science and Photochemistry,2004,22(5):363-369. |
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| Authors: | XIA Sheng-qin CHEN Jing-rong WANG Xue-song ZHANG Bao-wen |
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| Institution: | Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100101, P. R. China |
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| Abstract: | A new glycose derivatized hypocrellin B was synthesized in a facile way.The water-solubility and the absorbance in the phototherapeutic window was enhanced in the resulting product over hypocrellin B.Electron spin resonance (ESR) measurements indicated that this glycoside remained the photodynamic capability of generating ~1O_2,O_2~(·-),~·OH, and semiquinone anion radical. |
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| Keywords: | hypocrellin B glucosamine water-solubility reactive oxygen |
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