Facile synthesis of O6-alkyl-, O6-aryl-, and diaminopurine nucleosides from 2'-deoxyguanosine |
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| Authors: | Lakshman Ngassa Keeler Dinh Hilmer Russon |
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| Institution: | Department of Chemistry, University of North Dakota, Grand Forks 58202-9024, USA. mlakshman@mail.chem.und.nodak.edu |
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| Abstract: | The 3',5'-bis-O-TBDMS derivative of 2'-deoxyguanosine can be converted to its O6-alkyl and O6-aryl ethers as well as to N6-substituted diaminopurine nucleosides in two simple steps. Also described is a novel, nonaqueous, one-step O6-desulfonylation method that leads to deprotection of the carbonyl moiety of 2'-deoxyguanosine. |
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