Two procedures for the syntheses of labeled sialic acids and their 1,7-lactones |
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Authors: | Pietro AlleviMario Anastasia Maria L CostaPaola Rota |
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Institution: | Department of Chemistry, Biochemistry and Biotechnology for the Medicine, University of Milan, via Saldini 50, Milan, Italy |
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Abstract: | The synthesis of four deuterated sialic acids and their 1,7-lactones has been performed in two ways, one based on sialic acid classical chemistry, and the other involving a direct exchange of the unlabeled acyl group of N-acetylneuraminic acid with a labeled one mediated by a perfluorinated amide. The final lactonization is promoted by benzyloxycarbonyl chloride. |
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