Asymmetric hydrogenations of ketones catalyzed by Ru–achiral phosphine-enantiopure diamine complexes |
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| Authors: | Yu-Qing Xia Yuan-You Tang Zhi-Ming Liang Chang-Bin Yu Xiang-Ge Zhou Rui-Xiang Li Xian-Jun Li |
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| Institution: | Key Lab of Green Chemistry and Technology, Ministry of Education, Department of Chemistry, Sichuan University, Chengdu, Sichuan 610064, PR China |
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| Abstract: | Five novel ruthenium complexes, RuCl2(MOTPP)2(S,S)-DPEN] MOTPP = tris(4-methoxyphenyl)phosphine] (1), RuCl2(TFTPP)2(S,S)-DPEN] TFTPP = tris(4-trifluoromethylphenyl)phosphine] (2), RuCl2(PPh3)2(S,S)-DPEN] (3), RuCl2(BDPX)(S,S)-DPEN] BDPX = 1,2-bis(diphenylphosphinomethyl)benzene] (4), RuCl2(BISBI)(S,S)-DPEN]BISBI = 2,2′-bis((diphenylphosphino)methyl)-1,1′-biphenyl]] (5) were synthesized and used for the hydrogenation of aromatic ketones. The complexes showed high catalytic activities, especially that the catalytic activity of complex 5 containing the diphosphine with large bite angle and complex 1 containing triarylphosphine with electron-donating group were higher than the other three complexes. The enantioselectivities of products were almost not influenced by the electron factors of phosphine. |
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| Keywords: | Ruthenium complex Phosphine Asymmetric hydrogenation Diamine Aromatic ketone |
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