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Montmorillonite KSF-catalyzed one-pot synthesis of hexahydro-1H-pyrrolo[3,2-c]quinoline derivatives
Authors:JS Yadav  BV Subba Reddy  V Sunitha  K Srinivasa Reddy  KVS Ramakrishna
Institution:Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India
Abstract:Aryl amines react with endocyclic ene-carbamates such as tert-butyl 2,3-dihydro-1H-1-pyrrolecarboxylate and tert-butyl 1,2,3,4-tetrahydro-1-pyridinecarboxylate, on the surface of montmorillonite KSF clay under mild conditions to afford the corresponding 3-aminopropylhexahydropyrrolo3,2-c]quinoline or 4-aminobutyloctahydrobenzoh]1,6]naphthyridine derivatives in excellent yields with moderate diastereoselectivity.
Keywords:Ene-carbamates  Aryl amines  Hetero-Diels-Alder reaction  Pyrroloquinolines
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