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Stereoselective synthesis of the cyclic ether core of (+)-laurenyne |
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| Authors: | J. Stephen Clark Rebecca P. Freeman Andrew W. Thomas Claire Wilson |
| Affiliation: | a School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK b F. Hoffmann-LaRoche AG, Discovery Chemistry, Pharmaceuticals Division, Bldg. 92-6.88, 4070 Basel, Switzerland c Roche Products Limited, 40 Broadwater Road, Welwyn Garden City, Herts AL7 3AY, UK |
| Abstract: | A concise enantioselective synthesis of the cyclic ether core of the marine natural product (+)-laurenyne has been accomplished using ring-closing metathesis for medium-ring construction. |
| Keywords: | Marine natural product Cyclic ether Ring-closing metathesis |
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