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Solution-phase parallel synthesis of new 2H-pyrimido-[4,5-e][1,2,4]triazin-3-ylidenecyanamides |
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| Authors: | Ill Young Lee Sang Yo Kim Chan-Mo Yu Young-Dae Gong |
| Affiliation: | a Medicinal Science Division, Korea Research Institute of Chemical Technology, PO Box 107, Yusong, Taejon 305-600, Korea b Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea c Department of Chemistry, Sogang University, Seoul 121-742, Korea |
| Abstract: | A practical synthesis of 2H-pyrimido[4,5-e][1,2,4]triazin-3-ylidenecyanamides has been developed. The key step is the coupling reaction of an aryldiazonium salt with 1-cyano-3-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-ylamino)-2-methylisothiourea followed by intramolecular cyclization. A library of 2H-pyrimido[4,5-e][1,2,4]triazin-3-ylidenecyanamides was prepared in two steps from 6-aminouracils using this method. |
| Keywords: | 2H-Pyrimido[4,5-e][1,2,4]triazin-3-ylidenecyanamides Pyrimidotriazine Solution-phase parallel synthesis |
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