Heck reaction with an acyl synthon: new coupling reaction between α-halo vinyl ether and alkene |
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| Authors: | Xiaobang Gao |
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| Institution: | Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA |
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| Abstract: | α-Halo vinyl ethers were successfully applied to palladium-catalyzed Heck reaction. Reactions of α-halo vinyl ether with alkenes under various Heck conditions form a new carbon-carbon bond along with a vinyl ether functionality, which can be further manipulated. This is the first synthetic methodology for the coupling of an acyl synthon with alkene employing Heck reaction. |
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| Keywords: | α-Halo vinyl ether Heck reaction Vinyl ether Masked ketone |
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