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Bicyclic amido compounds with antiprotozoal activity |
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| Authors: | Johanna Faist Werner Seebacher Marcel Kaiser Reto Brun Robert Saf and Robert Weis |
| Institution: | (1) Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, Karl-Franzens University of Graz, Universit?tsplatz 1, 8010 Graz, Austria;(2) Swiss Tropical Institute, Socinstra?e 57, 4002 Basel, Switzerland;(3) Institute of Chemical Technology of Organic Materials, Erzherzog Johann University, Stremayrgasse 26/1, 8010 Graz, Austria; |
| Abstract: | AbstractAroyl derivatives of 2-aminobicyclo-octanes and 2-azabicyclo-nonanes have been synthesized and tested for their activities against the causative organisms of East African trypanosomiasis and malaria tropica. The acylation induced in general loss of antiprotozoal activity, but a single compound showed good antiplasmodial activity against a multiresistant strain of Plasmodium falciparum. |
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