| 多价环状模板法合成交联胶束和类环胶体 |
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| 引用本文： | 张淼,彭金磊,刘映,刘芳君,马伟,魏华.多价环状模板法合成交联胶束和类环胶体[J].高等学校化学学报,2021,42(11):3526. |
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| 作者姓名： | 张淼 彭金磊 刘映 刘芳君 马伟 魏华 |
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| 作者单位： | 1.南华大学药学院, 湖南省分子靶向新药协同创新中心, 衡阳 421001;2.兰州大学化学化工学院, 应用有机化学国家重点实验室, 甘肃省有色金属化学与资源利用重点实验室, 兰州 730000 |
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| 基金项目： | 国家自然科学基金(51473072);国家“青年千人计划”和湖南省教育厅一般项目(19C1597) |
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| 摘 要： | 通过点击偶联法, 用二茂铁（Fc）修饰环状聚甲基丙烯酸羟乙酯c-P(HEMA)50]的侧链羟基, 得到多价环状聚合物模板c-P(HEMA-Fc)50, 该模板可通过β-CD/Fc的主客体识别作用, 在Fc位点有序偶联以亲水聚乙二醇（PEG）和硫辛酸（LA）功能化的β-环糊精（β-CD）, 形成具有明显核壳结构的超分子胶束c-P(HEMA-Fc)50/β-CD-PEG-LA]. 该超分子胶束可通过二硫苏糖醇（DTT）催化的分子内自交联（CL）形成交联的超分子胶束, 作为交联β-CD-PEG-LA的环状胶体前驱体. 与三臂星状聚合物模板相比, 环状聚合物模板的优势在于环状多价结构具有更高的稳定性和空间位阻效应, 以环状聚合物为模板制备的交联胶束和类环胶体的胶束前驱溶液的浓度可显著提高至1.0 mg/mL.
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| 关 键 词： | 交联胶束 类环胶体 多价环状模板 |
| 收稿时间： | 2021-05-31 |
Synthesis of Crosslinked Micelles and Ring-like Colloids via a Cyclic Template with Multivalency |
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| ZHANG Miao,PENG Jinlei,LIU Ying,LIU Fangjun,MA Wei,WEI Hua.Synthesis of Crosslinked Micelles and Ring-like Colloids via a Cyclic Template with Multivalency[J].Chemical Research In Chinese Universities,2021,42(11):3526. |
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| Authors: | ZHANG Miao PENG Jinlei LIU Ying LIU Fangjun MA Wei WEI Hua |
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| Institution: | 1.Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study，Department of Pharmacy and Pharmacology，University of South China，Hengyang 421001，China;2.State Key Laboratory of Applied Organic Chemistry，Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province，College of Chemistry and Chemical Engineering，Lanzhou University，Lanzhou 730000，China |
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| Abstract: | The pendant hydroxyl groups of c-P（HEMA）50 were first decorated with ferrocene（Fc） by click coupling to afford c-P（HEMA-Fc）50， which was then used as a core template to direct the supramolecular comple-xation with β-cyclodextrin（β-CD） functionalized with both hydrophilic poly（ethylene glycol）（PEG） and lipoic acid（LA）（β-CD-PEG-LA） viaβ-CD/Fc host-guest inclusion complexation. The resulting supramolecular micelle formed by c-P（HEMA-Fc）50/β-CD-PEG-LA could be crosslinked via dithiothreitol（DTT）-catalyzed intramolecular self-crosslinking of the decorated LA units to serve as a precursor of the ring-like colloids of crosslinked β-CD-PEG-LA. The advantage of this cyclic polymer over the previously used three-arm star-shaped polymer as a template lies in the multivalent structure of the cyclic polymer with greater stability and steric hindrance， which results in a significantly increased preparation concentration of 1.0 mg/mL for the ring-like colloids. |
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| Keywords: | Crosslinked micelle Ring-like colloid Multivalent cyclic template |
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