| 硒化合物诱导细胞凋亡的信号转导机制 |
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| 引用本文： | 徐辉碧,杨祥良,刘琼,王海涛,甘璐.硒化合物诱导细胞凋亡的信号转导机制[J].化学进展,2002,14(4):305-310. |
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| 作者姓名： | 徐辉碧 杨祥良 刘琼 王海涛 甘璐 |
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| 作者单位： | 华中科技大学化学系 武汉 430074 |
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| 摘 要： | 从硒化合物诱导细胞凋亡及其机理阐明硒防治肿瘤的生物功能，是当今硒的生物无机化学与相关学科交叉的前沿。本文通过作者的研究工作及国内外有关工作介绍了活性氧（ROS）介导的硒化合物诱导细胞凋亡的信号转导机制，阐述了ROS作为信号分子的特性及硒化合物与ROS作用的化学基础。
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| 关 键 词： | 硒化合物 活性氧 细胞凋亡 信号传导 |
| 文章编号： | 1005-281X(2002)04-0305-06 |
The Signal Transduction in ROS-Mediated Apoptosis Induced by Selenium Compounds |
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| Xu Huibi,Yang Xiangliang,Liu Qiong,Wang Haitao,Gan Lu.The Signal Transduction in ROS-Mediated Apoptosis Induced by Selenium Compounds[J].Progress in Chemistry,2002,14(4):305-310. |
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| Authors: | Xu Huibi Yang Xiangliang Liu Qiong Wang Haitao Gan Lu |
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| Institution: | Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, China |
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| Abstract: | The biological function of selenium in preventing cancer can be explained by inducing apoptosis of tumor cells. This is an interdisciplinary frontier of the bioinorganic chemistry of selenium and its related subjects. Based on the newest studies and the authors' research results, the mechanism of signal transduction in ROS mediated apoptosis induced by selenium compounds is introduced, the characters of ROS as signal molecules and the chemical bases of the interactions between selenium compounds and ROS are elaborated. |
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| Keywords: | selenium ROS apoptosis signal transduction |
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