Reactions of CF3-enones with ethyl nitroacetate and nitromethane: synthesis of CF3-γ-nitroketones |
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| Authors: | Valentine G Nenajdenko Sergey V Druzhinin Elizabeth S Balenkova |
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| Institution: | Moscow State University, Department of Chemistry, Leninskie Gory, Moscow 119992, Russia |
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| Abstract: | Reactions of α,β-unsaturated CF3-ketones with nitromethane and ethyl nitroacetate have been investigated. We found that α,β-unsaturated trifluoromethylketones react with ethyl nitroacetate in the presence of calcinated potassium fluoride to form two classes of 1,4-conjugated addition products: CF3-γ-nitroketones and 6,6,6-trifluoro-2-nitro-5-oxohexanoates in nearly quantitative yields. The products obtained are precursors for CF3-pyrrolidine synthesis. |
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| Keywords: | CF3-Enones γ-Nitroketones Michael addition CF3-Groups Nitromethane Nitroacetate |
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