Chiral sulfideoxathiane ligands for palladium-catalyzed asymmetric allylic alkylation |
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| Affiliation: | 1. Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260-3000, United States;2. Institute for Lasers, Photonics and Biophotonics, Department of Chemistry, State University of New York, Buffalo, NY 14260, United States;3. Laboratorio di Biologia Vascolare e Medicina Rigenerativa, Centro Cardiologico Monzino, Istituto di Ricerca e Cura a Carattere Scientifico, 20138 Milan, Italy;4. Laboratorio di Patologia Vascolare, Istituto Dermopatico dell''Immacolata, IRCCS, 00167 Rome, Italy;5. Istituto di Patologia Medica, Università Cattolica del Sacro Cuore, 00168 Rome, Italy;6. Unità di Neurogenetica, Istituto CSS-Mendel, 00198 Rome, Italy;12. Laboratorio di Cardiologia Molecolare, Policlinico San Donato, IRCCS, 20097 Milan, Italy;8. Dipartimento di Chimica e Tecnologie del Farmaco, Università degli Studi di Roma “Sapienza”, 00185 Rome, Italy;9. Istituto di Biologia Cellulare e Neurobiologia, Consiglio Nazionale delle Ricerche (CNR), 00185 Rome, Italy;10. Division of Cardiovascular Epigenetics, Department of Cardiology, Goethe University, 60590 Frankfurt am Main, Germany |
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| Abstract: | 
Easily prepared, chiral sulfideoxathiane ligands are described, which give excellent enantioselectivities (up to 99% ee) in the Pd-catalyzed allylic alkylation of 1,3-diphenyl-2-propenyl acetate with a range of alkyl malonate nucleophiles. |
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