Chiral separation of halogenated amino acids by ligand-exchange capillary electrophoresis |
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Authors: | Koidl Julia Hödl Heike Schmid Martin G Pantcheva Svetlana Pajpanova Tamara Gübitz Gerald |
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Institution: | Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, Karl-Franzens-University, Graz, Austria. |
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Abstract: | The chiral separation of halogenated amino acids by ligand-exchange CE is described. Halogenated amino acids attracted increasing interest in recent years because of their physiological activities. Different chiral selectors, as there are L-4-hydroxyproline, L-histidine, and N-alkyl derivatives of L-4-hydroxyproline in form of their copper(II) complexes, are compared for their chiral recognition ability for halogenated amino acids. The influence of various parameters, such as selector concentration, pH, organic modifier, and field strength, on the resolution was investigated. All halogenated amino acids investigated were baseline-separated under optimized conditions. |
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Keywords: | Capillary electrophoresis Enantiomer separation Halogenated amino acids Ligand‐exchange |
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