| 氨肽酶N荧光探针的研究进展 |
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| 引用本文： | 王建国,李纯斌,姜国玉.氨肽酶N荧光探针的研究进展[J].化学通报,2018,81(11):972-980. |
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| 作者姓名： | 王建国 李纯斌 姜国玉 |
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| 作者单位： | 赣南师范大学 江西省有机药物重点实验室 江西 赣州 341000,赣南师范大学 江西省有机药物重点实验室 江西 赣州 341000,赣南师范大学 江西省有机药物重点实验室 江西 赣州 341000 |
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| 基金项目： | 国家自然科学基金项目（21502022, 21663005） |
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| 摘 要： | 氨肽酶N(aminopeptidase N,APN)是一种外肽酶,广泛存在于哺乳动物体内,可从蛋白质多肽链的N末端水解中性或碱性氨基酸,在人体中具有多种重要的生理功能。APN可作为癌症诊断的标志物,尿液中APN也可作为肾小球肾炎的早期生物标志物。本文综述了APN荧光探针的研究进展,主要包括亲和力型APN荧光探针和反应型APN荧光探针,并对它们的优缺点进行了比较;最后对APN荧光探针的发展前景进行了展望。
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| 关 键 词： | 氨肽酶N 荧光探针 亲和力型探针 反应型探针 |
| 收稿时间： | 2018/7/4 0:00:00 |
| 修稿时间： | 2018/7/25 0:00:00 |
Progressin fluorescent probes for aminopeptidase N |
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| Jianguo Wang,Chunbin Li and Guoyu Jiang.Progressin fluorescent probes for aminopeptidase N[J].Chemistry,2018,81(11):972-980. |
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| Authors: | Jianguo Wang Chunbin Li and Guoyu Jiang |
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| Institution: | Gannan Normal University,Key Laboratory of Organo-pharmaceutical Chemistry,Ganzhou,Jiangxi Province,341000,Gannan Normal University,Key Laboratory of Organo-pharmaceutical Chemistry,Ganzhou,Jiangxi Province,341000,Gannan Normal University,Key Laboratory of Organo-pharmaceutical Chemistry,Ganzhou,Jiangxi Province,341000 |
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| Abstract: | Aminopeptidase N (APN) is an exopeptidase that widely exists in the body of mammals. It is recognized to have various physiological functions in human body. Herein, the development of fluorescent probes for aminopeptides N was reviewed and generally divided into two categories: affinity based fluorescent probes and reaction based fluorescent probes, with their advantages and shortcomings compared, which may illuminate the future development of APN fluorescent probes. |
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| Keywords: | Aminopeptidase N Fluorescent probe Affinity based probes Reaction based probes |
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