Electrocatalytic oxidation and sensitive detection of deferoxamine on nanoparticles of Fe2O3@NaCo[Fe(CN)6]-modified paste electrode

Electrocatalytic oxidation of deferoxamine was studied on carbon paste electrodes modified with nanoparticles of iron(III) oxide core-cobalt hexacyanoferrate-shell using cyclic voltammetry and chronoamperometry. Voltammetric curves represented two quasi-reversible redox transitions which in the presence of deferoxamine, the two anodic peak currents increased, followed by decreases in the corresponding cathodic currents. This indicated that deferoxamine was oxidized on the immobilized cobalt hexacyanoferrate via two electrocatalytic steps. The rate constants, the electron transfer coefficients and the diffusion coefficient involved in the electrocatalytic oxidation of deferoxamine were reported. A sensitive and time-saving determination procedure was developed for the analysis of the drug in both batch and flow systems, and the corresponding analytical parameters were reported. The proposed amperometric method was also successfully applied to the direct assays of spiked human serum with iron–drug complex.