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Identification of archaeal proteins that affect the exosome function in vitro |
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| Authors: | Juliana S Luz Celso RR Ramos Márcia CT Santos Patricia P Coltri Fernando L Palhano Debora Foguel Nilson IT Zanchin Carla C Oliveira |
| Institution: | 1.Department of Biochemistry, Institute of Chemistry,University of S?o Paulo,S?o Paulo,Brazil;2.Center for Structural Molecular Biology,Brazilian Synchrotron Light Laboratory, LNLS,Campinas,Brazil;3.Institute of Medical Biochemistry, CCS,Federal University of Rio de Janeiro,Rio de Janeiro,Brazil;4.Department of Helminthology,Fiocruz,Rio de Janeiro,Brazil;5.Department of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA,University of California,Santa Cruz,USA |
| Abstract: | BackgroundThe archaeal exosome is formed by a hexameric RNase PH ring and three RNA binding subunits and has been shown to bind and degrade RNA in vitro. Despite extensive studies on the eukaryotic exosome and on the proteins interacting with this complex, little information is yet available on the identification and function of archaeal exosome regulatory factors. |
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