Entrapment of organic fluorophores in calcium phosphate nanoparticles with slow release |
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| Authors: | Laila SADALLAH Aicha BOUKHRIS Hassan HANNACHE Said GMOUH |
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| Institution: | 1. Department of Chemistry, Faculty of Science Ben M’sik, Hassan II University of Casablanca, Casablanca, Morocco ; 2. Higher School of Textile and Clothing Industries, Casablanca, Morocco ; 3. Department of Materials Science and Nanoengineering, Mohamed VI Polytechnic University, Benguerir, Morocco |
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| Abstract: | Two organic fluorophores, fluorescein (F) and rhodamine B (Rd), were entrapped in calcium phosphate nanoparticles. The as-obtained nanoparticles can be used for biological release applications. For this aim, calcium phosphate nanoparticles were synthesized using the precipitation method. Structural analysis of these nanoparticles was performed using XRD, FTIR, and Raman spectroscopy, confirming that the synthesized nanoparticles were hydroxyapatite. TEM and SEM analyses demonstrated that these nanoparticles had a size of 20 nm and a well-defined morphology. F and Rd (about 0.5 wt.%) were entrapped in these nanoparticles and their release, as a function of time, was studied via UV-Vis spectroscopy. The obtained results showed that the release of both fluorophores was progressive over time. The trapping efficiencies of the fluorophores were 67.15% and 90.76% for F and Rd, respectively. |
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| Keywords: | Calcium phosphate nanoparticles slow release entrapment organic fluorophores |
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