Electrospray Ionization Mass Spectrometry (ESI-MS) as a Useful Tool for Fast Evaluation of Anion and Cation Complexation Abilities of a Cyclam Derivative |
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| Authors: | Ignacio Alfonso Covadonga Astorga Vicente Gotor |
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| Institution: | (1) Departamento de Química Inorgánica y Orgánica , Universidad Jaume I, E-12071 Castellón, Spain;(2) Departamento de Química Orgánica e Inorgánica. Facultad de Química, Universidad de Oviedo, E-33006 Oviedo, Spain |
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| Abstract: | Electrospray ionization mass espectrometry (ESI-MS) has been used for the study of a cyclam derivative noncovalent interactions.
At acidic pH, diprotonated macrocycle bound to different anionic species were observed. The selectivity shown by competitive
experiments is rationalized with the help of semiempirical theoretical calculations. At basic pH, the base peak corresponded
to the macrocycle-alkaline metal complexes, and again competition experiments showed different binding strength. Finally,
experiments carried out in the presence of transition metal salts allowed the detection of the complexes present in the mixture
and revealed their different kinetic behavior. |
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| Keywords: | anion coordination cyclam electrospray ionization mass spectrometry macrocycles metal coordination supramolecular chemistry |
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