Acetylenic derivatives of betulonic acid amide as a new type of compounds possessing spasmolytic activity |
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| Authors: | A. I. Govdi I. V. Sorokina D. S. Baev A. O. Bryzgalov T. G. Tolstikova G. A. Tolstikov S. F. Vasilevsky |
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| Affiliation: | 1.V. V. Voevodsky Institute of Chemical Kinetics and Combustion,Siberian Branch of the Russian Academy of Sciences,Novosibirsk,Russian Federation;2.N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry,Siberian Branch of the Russian Academy of Sciences,Novosibirsk,Russian Federation;3.Novosibirsk State Pedagogical University,Novosibirsk,Russian Federation;4.Novosibirsk State University,Novosibirsk,Russian Federation |
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| Abstract: | ![]()
Efficient and versatile synthetic procedures towards novel derivatives of betulonic acid via Mannich reaction, Sonogashira cross-coupling, and copper(i)-catalyzed 1,3-dipolar cyclo-additions were developed. Introduction of secondary amines (Mannich reaction) into betulonic acid amides led to derivatives possessing marked spasmolytic activity, which is not characteristic of the triterpene fragment. |
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