| Palladium-catalyzed 2-pyridylmethyl-directed β-C(sp~3)—H activation and cyclization of aliphatic amides with gem-dibromoolefins:A rapid access to γ-lactams |
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| 作者姓名： | Danni Zhou Chunxia Wang Mingliang Li Zheng Long Jingbo Lan |
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| 作者单位： | Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China |
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| 基金项目： | We are grateful for the financial supports from the National Natural Science Foundation of China (Nos. 21672154 and 21372164). We thank the Comprehensive Training Platform of Specialized Laboratory, College of chemistry, Sichuan University, for NMR measurements and HRMS measurements. |
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| 摘 要： | The direct Pd-catalyzed β-C(sp3) H activation and cyclization of aliphatic amides bearing a removable 2-pyridylmethyl directing group with gem-dibromoolefins is described for the first time to construct a variety of γ-lactams.
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| 关 键 词： | C (sp3)-H activation Palladium-catalyzed gem-Dibromoolefins Removable directing group &gamma -Lactams |
| 收稿时间： | 2017-04-18 |
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