| First identification of isatin-β-thiosemicarbazones as novel inhibitors of New Delhi metallo-β-lactamase-1: Chemical synthesis,biological evaluation and molecular simulation |
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| 作者姓名： | Guo-Qing Song Wei-Min Wang Zai-Shun Li Ying Wang Jian-Guo Wang |
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| 作者单位： | a State-Key Laboratory and Research Institute of Elemento-Organic Chemistry, National Pesticide Engineering Research Center, College of Chemistry, Nankai University, Tianjin 300071, China;
b Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China;
c Patent Examination Cooperation Jiangsu Center of the Patent Office, SIPO, Suzhou 215163, China |
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| 基金项目： | This work was supported by the "111" Project of Ministry of Education of China (No. B06005), the National Natural Science Foundation of China (No. 21672114) and the National Basic Research Program of China (No. 2013CB734004). |
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| 摘 要： | A series of isatin-β-thiosemicarbazone compounds were identified as novel inhibitors of New Delhi metallo-β-lactamase-1. The structure-activity relationship and possible binding mode were also established for further rational design of new inhibitors.
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| 收稿时间： | 2017-06-30 |
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