ACUTE SKIN RESPONSE IN ALBINO MICE FOLLOWING PORPHYRIN PHOTOSENSITIZATION UNDER OXIC AND ANOXIC CONDITIONS |
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| Authors: | Charles J Gomer Nicholas J Razum |
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| Institution: | Clayton Center for Ocular Oncology, Childrens Hospital of Los Angeles;Departments of Pediatrics (Division of Hematology-Oncology), USC School of Medicine, Los Angeles, CA 90027, USA;Departments of Ophthalmology, USC School of Medicine, Los Angeles, CA 90027, USA |
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| Abstract: | Abstract Acute normal skin toxicity induced by porphyrin photosensitization has been examined using albino mice. Oxic and anoxic (clamped) skin was exposed to red light (630 nm) 24 h following administration of hematoporphyrin derivative (HpD) or Photofrin II (the active component of HpD). Experiments were also performed to determine the effect of sodium pentobarbital anesthesia on HpD and Photofrin II photosensitization of normal skin. Results from this study demonstrated that comparable levels of acute skin damage were induced by HpD and Photofrin II under oxic conditions but neither porphyrin produced any apparent phototoxicity under anoxic conditions. In addition, the level of skin damage induced by porphyrin photosensitization was not affected by sodium pentobarbital anesthesia. |
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