| 2,5-二取代-1,3,4-噻二唑衍生物的合成与表征 |
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| 引用本文： | 李英俊,陈晓臣,靳焜,丁万刚.2,5-二取代-1,3,4-噻二唑衍生物的合成与表征[J].化学通报,2012(9):827-831. |
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| 作者姓名： | 李英俊 陈晓臣 靳焜 丁万刚 |
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| 作者单位： | 辽宁师范大学化学化工学院;大连理工大学精细化工国家重点实验室 |
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| 摘 要： | 苯并噁唑啉酮和1,3,4-噻二唑衍生物具有多种生物活性,制备含有苯并噁唑啉酮结构的1,3,4-噻二唑衍生物非常有意义。本文以邻氨基苯酚和尿素为初始原料,经多步合成反应,制备了10个新的2-(芳甲酰氨基)-5-(2-苯并噁唑啉酮-3-甲基)-1,3,4-噻二唑化合物(7a～7j),并利用IR、1H NMR和元素分析对其结构进行了表征。
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| 关 键 词： | 苯并噁唑啉酮 1 3 4-噻二唑 合成 表征 |
Synthesis and Characterization of 2,5-Disubstituted-1,3,4-thiadiazole Derivatives |
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| Li Yingjun,Chen Xiaochen,Jin Kun,Ding Wangang.Synthesis and Characterization of 2,5-Disubstituted-1,3,4-thiadiazole Derivatives[J].Chemistry,2012(9):827-831. |
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| Authors: | Li Yingjun Chen Xiaochen Jin Kun Ding Wangang |
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| Institution: | 1(1College of Chemistry and Chemical Engineering,Liaoning Normal University,Dalian 116029; 2State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian 116012) |
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| Abstract: | In view of various biological activities of benzoxazolinone and thiadiazole derivatives,the preparation of 1,3,4-thiadiazole derivatives containing benzoxazolinone moiety is of great significance.In this paper,ten novel 2-arylformylamino-5-(2-benzoxazolinone-3-yl)methyl-1,3,4-thiadiazoles(7a~7j) were synthesized by 2-aminophenol and urea as the starting materials via a series of reactions.The structures of the target compounds were characterized by IR,1H NMR and elemental analysis. |
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| Keywords: | Benzoxazolinone 1 3 4-Thiadiazole Synthesis Characterization |
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