InBr3-catalyzed reduction of ketones with a hydrosilane: deoxygenation of aromatic ketones and selective synthesis of secondary alcohols and symmetrical ethers from aliphatic ketones |
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| Authors: | Norio Sakai Ken NagasawaReiko Ikeda Yumi NakaikeTakeo Konakahara |
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| Affiliation: | Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan |
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| Abstract: | An InBr3-Et3SiH reducing system was developed to selectively convert aliphatic ketones to a variety of secondary alcohols in moderate to good yields. An initial mixing of InBr3 and PhSiH3 was followed by the addition of aliphatic ketones and a solvent to afford the symmetrical ether derivatives. |
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| Keywords: | Reduction Indium Silane Ether Alcohol |
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