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Tissue-specific and neural activity-regulated expression of human BDNF gene in BAC transgenic mice
Authors:Indrek Koppel   Tamara Aid-Pavlidis   Kaur Jaanson   Mari Sepp   Priit Pruunsild   Kaia Palm  T?nis Timmusk
Affiliation:(1) Department of Gene Technology, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia
Abstract:

Background  

Brain-derived neurotrophic factor (BDNF) is a small secreted protein that has important roles in the developing and adult nervous system. Altered expression or changes in the regulation of the BDNF gene have been implicated in a variety of human nervous system disorders. Although regulation of the rodent BDNF gene has been extensively investigated, in vivo studies regarding the human BDNF gene are largely limited to postmortem analysis. Bacterial artificial chromosome (BAC) transgenic mice harboring the human BDNF gene and its regulatory flanking sequences constitute a useful tool for studying human BDNF gene regulation and for identification of therapeutic compounds modulating BDNF expression.
Keywords:
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