Folate Conjugated CdHgTe Quantum Dots with High Targeting Affinity and Sensitivity for In vivo Early Tumor Diagnosis |
| |
Authors: | Haiyan Chen Li Li Sisi Cui Dider Mahounga Jun Zhang Yueqing Gu |
| |
Institution: | (1) Department of Biomedical Engineering, School of Life Science and Technology, China Pharmaceutical University, 24 Tongjia Lane, Gulou District, Nanjing, 210009, China;(2) XinXiang College of Chemistry and Chemical Engineering, Xinxiang University, XinXiang City, 453003,, Henan Province, China;(3) China Pharmaceutical University, Nanjing, China; |
| |
Abstract: | CdHgTe-folate conjugates, acting as novel active-targeting fluorescence probes, were prepared by covalent conjugation of CdHgTe
QDs and folic acid. Their characteristics, such as optical spectra, stability and cancer cell targeting were investigated
in detail. The fluorescence wavelength of CdHgTe-folate conjugates was 790 nm and a full width at half-maximum (FWHM) of them
was 50–70 nm. Their fluorescence stability could satisfy the need of long and continuous fluorescence imaging. The in vivo
dynamic bio-distribution of CdHgTe-folate conjugates in S180 tumor beard mouse model was monitored by a NIR imaging system.
The resultes indicated that CdHgTe-folate conjugates targeted to tumor effectively. The high fluorescence intensity together
with targeting effect makes CdHgTe-folate conjugates promising candidates for imaging, monitoring and early diagnosis of cancer
at molecular and cell level. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|