Cu(I)-catalyzed intramolecular cyclization of alkynoic acids in aqueous media: a "click side reaction" |
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Authors: | Mindt Thomas L Schibli Roger |
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Institution: | Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland. thomas.mindt@pharma.ethz.ch |
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Abstract: | Alkynoic acids, in particular, 4-pentynoic acid derivatives, undergo intramolecular cyclizations to enol lactones under reaction conditions typically applied for the Cu(I)-catalyzed cycloaddition of terminal alkynes and azides (click chemistry). Starting from appropriate alkynoic acid derivatives, either enol lactones or 1,2,3-triazole click products can be obtained selectively by Cu(I) catalysis in aqueous media. |
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