Double decarboxylative Claisen rearrangement reactions: microwave-assisted de novo synthesis of pyridines |
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| Authors: | Craig Donald Paina Federica Smith Stephen C |
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| Affiliation: | Department of Chemistry, Imperial College London, South Kensington Campus, London, UK. d.craig@imperial.ac.uk |
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| Abstract: | ![]()
Microwave-assisted double decarboxylative Claisen rearrangement of bis(allyl) 2-tosylmalonates provides substituted 1,6-heptadienes, which may be alkylated, and then converted into pyridines by ozonolysis followed by reaction with ammonia generated in situ under microwave conditions. |
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