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Stability of a salicylate-based poly(anhydride-ester) to electron beam and gamma radiation |
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| Authors: | Rosario-Meléndez Roselin Lavelle Linda Bodnar Stanko Halperin Frederick Harper Ike Griffin Jeremy Uhrich Kathryn E |
| Affiliation: | a Rutgers, The State University of New Jersey, Department of Chemistry and Chemical Biology, 610 Taylor Road, Piscataway, NJ 08854, United States b Sterile Process Technology, Johnson & Johnson, 930 East Route 202, Raritan, NJ 08869, United States c Rutgers, The State University of New Jersey, Department of Biomedical Engineering, 599 Taylor Road, Piscataway, NJ 08854, United States |
| Abstract: | The effect of electron beam and gamma radiation on the physicochemical properties of a salicylate-based poly(anhydride-ester) was studied by exposing polymers to 0 (control), 25 and 50 kGy. After radiation exposure, salicylic acid release in vitro was monitored to assess any changes in drug release profiles. Molecular weight, glass transition temperature and decomposition temperature were evaluated for polymer chain scission and/or crosslinking as well as changes in thermal properties. Proton nuclear magnetic resonance and infrared spectroscopies were also used to determine polymer degradation and/or chain scission. In vitro cell studies were performed to identify cytocompatibility following radiation exposure. These studies demonstrate that the physicochemical properties of the polymer are not substantially affected by exposure to electron beam and gamma radiation. |
| Keywords: | Polyanhydride Sterilization Drug release Gamma irradiation Electron beam Stability |
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