Degradation of electrospun SF/P(LLA-CL) blended nanofibrous scaffolds in vitro |
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Authors: | Kuihua ZhangChen Huang Chunyang WangXiumei Mo Salem S Al-DeyabMohamed El-Newehy |
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Institution: | a College of Materials and Textile Engineering, Jiaxing University, Zhejiang 314001, China b Biomaterials and Tissue Engineering Lab, College of Chemistry and Chemical Engineering and Biological Engineering, Donghua University, Shanghai 201620, China c Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital, Jiao Tong University, Shanghai 200233, China d Petrochemical Research Chair, Department of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia e Department of Chemistry, Faculty of Science, Tanta University, Tanta 31527, Egypt |
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Abstract: | Nanofibrous scaffolds of silk fibroin (SF) and poly(l-lactic acid-co-?-caprolactone) (P(LLA-CL)) blends fabricated via electrospinning possessed good mechanical property and biocompatibility, as demonstrated by a previous study in vitro. However, the degradation behavior of the scaffolds, which may significantly influence tissue repair and regeneration, needs further exploration. In this study, in vitro degradation of pure SF, P(LLA-CL) and SF/P(LLA-CL) blended nanofibrous scaffolds were performed in phosphate-buffered saline (PBS, pH 7.4 ± 0.1) at 37 °C for 6 months. A series of analyses and characterizations (including morphologic changes, loss weight, pH changes of PBS solutions, DSC, XRD and FTIR-ATR) were conducted to the nanofibrous scaffolds after degradation and the results showed that the pure SF nanofibrous scaffolds were not completely degradable in PBS while pure P(LLA-CL) nanofibrous scaffolds had the fastest degradation rate. Moreover, the addition of SF reduced the degradation rate of P(LLA-CL) in SF/P(LLA-CL) blended nanofibrous scaffolds. This was probably caused by the intermolecular interactions between SF and P(LLA-CL), which hindered the movement of P(LLA-CL) molecular chains. |
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Keywords: | Degradation in  vitro SF/P(LLA-CL) nanofibrous scaffolds Mechanism Tissue repair |
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