A synthetic approach to (+)-aldosterone and its relatives (2)- a stereoselective synthesis of (+)-<span class="math"><math><mtext>trans</mtext></math></span>-4,5-(4-methoxybenzo)- 1β , 7aβ - ( 2α-methoxymethyl- 5 -oxofuro) hydrindane期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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A synthetic approach to (+)-aldosterone and its relatives (2)- a stereoselective synthesis of (+)- $trans$ -4,5-(4-methoxybenzo)- 1β , 7aβ - ( 2α-methoxymethyl- 5 -oxofuro) hydrindane

Authors:	Hideo Nemoto Mitsuo Nagai Keiichiro Fukumoto Tetsuji Kametani

Institution:	Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980, Japan;Institute of Medicinal Chemistry, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142, Japan

Abstract:	A stereoselectivity in an intramolecular cycloaddition of the olefinic $o$ -quinodimethanes 13 and 23 generated $in$ $situ$ from the thermolysis of optically active 4β-2-(4-methoxybenzocyclobutenyl)ethyl] -5α-methoxymethyl-3-phenyl-thio-methylenefuran-2-ones 12 and 22, respectively, is studied and a stereoselective synthesis of (+)- $trans$ -4,5-( 4-methoxybenzo) -1β,7aβ-(2α-methoxymethyl-5-oxofuro)hydrindane 1 is also described.

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