S-4-methylphenyl-o,o-bis[1-benzotriazolyl] phosphorothioate: a versatile phosphorylating agent |
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| Authors: | C.T.J. Wreesmann A. Fidder G.H. Veeneman G.A. van der Marel J.H. van Boom |
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| Affiliation: | Gorlaeus Laboratories, PO-Box 9502, 2300 Ra Leiden, The Netherlands |
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| Abstract: | The phosphorylating agent obtained by treatment of S-4-methylphenyl phosphorodichloridothioate with 1-hydroxybenzotriazole can not only be applied for the introduction of polyphosphate functions at the terminal ends of nucleic acids, but also for the formation of 3′-5′-phosphotriester linkages. |
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