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An efficient conversion of 1-abietic acid to (+)?3-deoxyaphidicolin |
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| Authors: | Hiroo Koyama Hideki Okawara Susumu Kobayashi Masaji Ohno |
| Institution: | Faculty of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan |
| Abstract: | The first total synthesis of (+)?3-deoxyaphidicolin, a selective inhibitor of eukaryotic DNA polymerase α, has been completed efficiently and stereoselectively starting from 1-abietic acid. |
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