FeO(OH)@C-Catalyzed Selective Hydrazine Substitution of p-Nitro-Aryl Fluorides and their Application for the Synthesis of Phthalazinones |
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| Authors: | Dingzhong Li Wensheng Zhang Dr. Longzhi Zhu Prof. Dr. Shuang-Feng Yin Prof. Dr. Nobuaki Kambe Prof. Dr. Renhua Qiu |
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| Affiliation: | 1. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082 P. R. China;2. Center for Biomedical Optics and Photonics (CBOP) & College of Physics and Optoelectronic Engineering, Key Lab of Optoelectronics Devices and systems of Ministry of Education/Guangdong Province, Shenzhen University, Shenzhen, 518060 P. R. China |
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| Abstract: | ![]()
An efficient hydrazine substitution of p-nitro-aryl fluorides with hydrazine hydrates catalyzed by FeO(OH)@C nanoparticles is described. This hydrazine substitutions of p-nitro-aryl fluorides bearing electron-withdrawing groups proceeded efficiently with high yield and selectivity. Similarly, hydrogenations of p-nitro-aryl fluorides containing electron-donating groups also smoothly proceeded under mild conditions. Furthermore, with these prepared aryl hydrazines, some phthalazinones, interesting as potential structures for pharmaceuticals, have successfully been synthesized in high yields. |
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| Keywords: | hydrazine substitution FeO(OH)@C nanoparticles industrial C. lanceolata carbon phthalazinones p-nitro-aromatic fluorides |
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