Fusarisetin A, an acinar morphogenesis inhibitor from a soil fungus, Fusarium sp. FN080326 |
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| Authors: | Jang Jae-Hyuk Asami Yukihiro Jang Jun-Pil Kim Sun-Ok Moon Dong Oh Shin Kee-Sun Hashizume Daisuke Muroi Makoto Saito Tamio Oh Hyuncheol Kim Bo Yeon Osada Hiroyuki Ahn Jong Seog |
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| Affiliation: | Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gun, Chungbuk 363-883, Republic of Korea. |
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| Abstract: | An acinar morphogenesis inhibitor named fusarisetin A (1) that possesses both an unprecedented carbon skeleton and a new pentacyclic ring system has been identified from an in-house fractionated fungal library using a three-dimensional matrigel-induced acinar morphogenesis assay system. The structure of 1 was determined in detail by NMR and circular dichroism spectroscopy, X-ray analysis, and chemical reaction experiments. |
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