Boronated derivatives of protohemin IX with L-amino acids as potential anticancer agents |
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| Authors: | A. N. Savchenko V. A. Ol’shevskaya V. N. Kalinin A. A. Shtil |
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| Affiliation: | (1) Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, Moscow, 119991, Russia;(2) Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Kashirskoe shosse 24, Moscow, 115478, Russia |
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| Abstract: | New water-soluble conjugates of protohemin IX with an anionic 1-carba-closo-dodecaborate polyhedron and L-amino acids have been synthesized. In these compounds, the amino acid residues are bound to the porphyrin ring through the amide or ester bond. The new water-soluble amino acid derivatives of boronated protohemin IX show high antitumor activity for human tumor cell lines. |
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