| 苯丙氨酸改性树枝状聚赖氨酸的合成及表征 |
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| 引用本文： | 郝挥红,史清洪,张猛,秦明,孙彦.苯丙氨酸改性树枝状聚赖氨酸的合成及表征[J].高分子学报,2006(3):450-454. |
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| 作者姓名： | 郝挥红 史清洪 张猛 秦明 孙彦 |
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| 作者单位： | 天津大学化工学院生物化工系,天津,300072 |
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| 摘 要： | 以双芴甲氧羰基赖氨酸(Di- Fmoc -Lysine)为支化单元采用固相多肽合成技术制备了一种树枝状聚赖氨酸.该聚合物表面活性氨基通过与芴甲氧羰基苯丙氨酸(Fmoc- Phe)反应获得表面完全替代的苯丙氨酸改性树枝状聚赖氨酸.产物的分子量和结构经MS和NMR进行了表征.研究结果表明,利用该方法得到的产物分子量单一,是一种潜在的理想非病毒治疗载体.
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| 关 键 词： | 非病毒载体 树枝状 多聚赖氨酸 表面改性 |
| 收稿时间： | 2004-12-28 |
| 修稿时间： | 2005-02-20 |
SYNTHESIS AND CHARACTERIZATION OF PHENYLALANINE-MODIFIED POLY (LYSINE) DENDRIMER |
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| HAO Huihong,SHI Qinghong,Zhang Meng,QIN Ming,SUN Yan.SYNTHESIS AND CHARACTERIZATION OF PHENYLALANINE-MODIFIED POLY (LYSINE) DENDRIMER[J].Acta Polymerica Sinica,2006(3):450-454. |
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| Authors: | HAO Huihong SHI Qinghong Zhang Meng QIN Ming SUN Yan |
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| Institution: | Department of Biochemical Engineering, School of Chemical Science and Technology, Tianjin University, Tianjin 300072 |
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| Abstract: | A tree-type full substituted phenylalanine-poly(lysine) dendrimer (Phe-PL dendrimer) was synthesized.Poly(lysine) dendrimer (generation 3) (PL dendrimer G3) was prepared using N,N′-di(fluorenylmethoxy-carbonyloxy)-L-Lysine as both the branching agent and the dendritic branch by solid phase peptide coupling method on 1% cross-linked polystyrene bead functionalized with Fmoc-glycine.Then Phenylalanine was bound to PL dendrimer G3 to form full substituted Phe-PL dendrimer.The product was characterized with MALDI-TOF MS and NMR.The results of MS demonstrated that they both Fmoc-PL and Phe-PL dendrimers G3 have exclusive molecular weights,indicating that they could be developed as a potential ideal nonviral vector. |
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| Keywords: | Nonviral vector Dendrimer Poly(lysine) Surface modification |
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