Thermal behavior of orthorhombic polymorphs I and II of spironolactone |
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Authors: | P Espeau B Nicolaï R Céolin M -A Perrin L Zaske J Giovannini F Leveiller |
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Institution: | 1.Laboratoire de Chimie Physique, EA 4066,Faculté de Pharmacie,Paris,France;2.AstraZeneca R and D,Lund,Sweden |
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Abstract: | Investigation into the thermal behavior of orthorhombic Forms I and II of spironolactone, by means of differential scanning
calorimetry and high-resolution X-ray powder diffraction, showed that Form I melts then recrystallizes into Form II at 373–393
K, i.e. in the temperature range within which high resolution X-ray powder diffration showed that Form I transforms into Form II.
Refinements of the lattice parameters of the two forms indicated that Form I is denser than Form II in the range from 298
K up to the temperature at which it melts. |
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