Monitoring of optical isomers of chiral alcohols and derivatives by chiral gas chromatography. Effect of derivatization on the enantio-differentiation |
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Authors: | Gy Szöllösi B Török M Bartók |
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Institution: | (1) Organic Catalysis Research Group of the Hungarian Academy of Sciences and Department of Organic Chemistry, József Attila University, Dóm tér 8, 6720 Szeged, Hungary |
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Abstract: | Summary Gas chromatographic chiral separation of several chiral 2-and 3-alkanols and diols was studied both in their free hydroxyl
and in their trimethylsilyl ether forms. First, the derivatization procedure was verified through the identification of the
trimethylsilyl ethers formed on the basis of their mass spectra and optimized to obtain quantitative reaction. The optimized
procedure was applied to the trimethylsilylation of racemic mixtures of various hydroxyl compounds. The silylation was found
to be highly effective in the improvement of the separation of the individual enantiomers. The major advantages of the derivatization
process can be summarized as: (i) excellent baseline separation of the enantiomers of the silyl ethers was achieved in contrast
to the parent OH-containing compounds, (ii) the sensitivity of detection highly increased, (iii) the separations do not show
any significant concentration dependence and finally (iv) the analysis time needed decreased significantly.
Presented at: Balaton Symposium on High-Performance Separation Methods, Siófok, Hungary, September 3–5, 1997 |
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Keywords: | Gas chromatography Chiral separation Alcohols Diols Trimethylsilylation |
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