TUMOR IMAGING WITH [111niIn]MONO-DTPA-ETHYLENEGLYCOL-Ga-DEUTEROPORPHYRIN |
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| Authors: | S Nakajima H Hayashi K OHSHIMA K Yamazaki Y Kubo N Samejima Y Kakiuchi Y Shindoh H Koshimizu I Sakata H Yamauchi |
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| Institution: | The 1st Department of Surgery, Asahikawa Medical College, Asahikawa 078, Japan;Department of Physiology, Hokkaido University, Institute of Applied Electricity, Sapporo 060, Japan;Department of Food Science &Technology, Kyoto University, School of Agriculture, Kyoto 606, Japan;Toyo-Hakka Co Ltd., Okayama 719-03, Japan;Nihon-Mediphysics, Chiba 299-02, Japan |
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| Abstract: | Abstract Mono-DPTA-ethyleneglycol-Ga-deuteroporphyrin (MDEGD) was synthesized, by coordinating non-radioactive Ga in the porphyrin ring and connecting DTPA (diethylene-triamine-N,N,N,N,N,-pentaacetic acid) to its side chain. By labeling with 111In, chemicals for scintigraphy were developed. They were applied to Syrian golden hamsters with implanted pancreatic gland cancers and C57-black mice with Lewis lung cancer to enable tumor imaging and biodistribution examination. A comparative study was also conducted with 67Ga]citrate. In the resultant data, 111In]MDEGD showed larger tumor/lung, tumor/kidney and tumor/blood ratio with 67Ga]citrate. The affinity of nIn]MDEGD in inflammatory tissue was much lower than that of 67Ga citrate. 111In]MDEGD lost its photosensitivity. |
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