| Abstract: | Furo2, 3-b]chromone ( 1a ) was conveniently prepared by the PPE-promoted cyclization of 5-(2′-carboxy-phenoxy)furan-2-carboxylic acid ( 8 ) which was made from methyl salicylate and ethyl 5-nitrofuran-2-carboxyl-ate. Furo2, 3-b]chromon-2-acrylic acid ( 13 ) was obtained by a similar cyclization. Direct acylation of 1a afforded 2-acetylfuro2, 3-b]chromone ( 10 ). Several derivatives of furo2, 3-b]chromone were found to display activity in the rat passive cutaneous anaphylaxis (PGA) test for antiallergic activity. |
