Naproxen drug delivery using periodic mesoporous silica SBA-15 |
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Authors: | Dáša Halamová Mária Badani?ová Ta?ána Gondová |
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Institution: | a Department of Inorganic Chemistry Faculty of Science, P.J. Šafárik University, Moyzesova 11, SK-041 54 Košice, Slovak Republic b Department of Analytical Chemistry Faculty of Science, P.J. Šafárik University, Moyzesova 11, SK-041 54 Košice, Slovak Republic c Hasylab, DESY, Notkestrasse 85, Hamburg, Germany |
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Abstract: | In this paper, we present the release of naproxen from hexagonal periodic mesoporous silica SBA-15, which serves as a drug delivery system. Naproxen, the well-known nonsteroidal anti-inflammatory drug (NSAID), was loaded into the pores of SBA-15 silica modified with aminopropyl groups. The physicochemical properties of the modified sample (A-SBA-15/napro) were compared with the unmodified SBA-15 mesoporous silica loaded with the drug (SBA-15/napro). The kinetic of the naproxen release into the physiological solution was studied. The released amount of naproxen represented 90.7% from the unmodified SBA-15 in 72 h, while from the sample A-SBA-15/napro the released amount represented about 80.9%. The prepared materials were characterized by nitrogen adsorption/desorption, Small angle X-ray scattering (SAXS), Fourier-transform infrared spectroscopy (FT-IR) and the thermoanalytical methods (TG/DTA). Thin layer chromatography (TLC) was used for quantitative determination of the released naproxen. |
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Keywords: | Mesoporous silica Naproxen Controlled release Drug delivery |
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