(1) Alzheimer's Disease Research Laboratory, Department of Pharmacology, University of South Florida, Tampa, USA
Abstract:
Background
The pathology of Alzheimer's disease (AD) is comprised of extracellular amyloid plaques, intracellular tau tangles, dystrophic
neurites and neurodegeneration. The mechanisms by which these various pathological features arise are under intense investigation.
Here, expanding upon pilot gene expression studies, we have further analyzed the relationship between Na+/K+ ATPase and amyloid
using APP+PS1 transgenic mice, a model that develops amyloid plaques and memory deficits in the absence of tangle formation
and neuronal or synaptic loss.