Synthesis of camptothecin-loaded gold nanomaterials |
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| Authors: | Zhimin Xing Zhiguo Liu Yuangang Zu Yujie Fu Chunjian Zhao Xiuhua Zhao Ronghua Meng Shengnan Tan |
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| Institution: | a Key Laboratory of Forest Plant Ecology of Ministry of Education, Northeast Forestry University, Harbin 150040, China
b Engineering Research Center of Forest Bio-preparation, Ministry of Education, Northeast Forestry University, Harbin 150040, China |
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| Abstract: | Camptothecin-loaded gold nanomaterials have been synthesized by the sodium borohydride reduction method under a strong basic condition. The obtained gold nanomaterials have been characterized by transmission electron microscopy (TEM), atomic force microscopy (AFM) and UV-vis absorption spectroscopy. The camptothecin-loaded gold colloidal solution was very stable and can be stored for more than two months at room temperature without obvious changes. The color of the colloidal solution can change from wine red to purple and blue during the acidifying process. It was revealed that the release of camptothecin and the aggregation of gold nanoparticles can be controlled by tuning the solution pH. The present study implied that the gold nanomaterials can be used as the potential carrier for CPT delivery. |
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| Keywords: | Gold nanoparticles Gold nanochains Camptothecin CPT TEM AFM |
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